Neonatal Infections & Sepsis Management

Neonatal infections and sepsis remain leading causes of morbidity and mortality in the first weeks of life, particularly in preterm and low birth weight infants. Advances in rapid molecular diagnostics and point-of-care testing now allow earlier identification of bacterial, viral, and fungal pathogens, reducing delays in initiating life-saving treatment. Antimicrobial stewardship programs are playing an essential role in minimizing resistance while ensuring effective therapy. Immunomodulatory strategies, maternal vaccination, and the use of probiotics are emerging as preventive measures to reduce infection risk. Improvements in infection control within neonatal intensive care units, including optimized catheter care and sterile procedures, are significantly lowering hospital-acquired sepsis rates. Early recognition tools supported by artificial intelligence are further enhancing clinicians’ ability to intervene quickly. Collectively, these innovations are strengthening the global fight against neonatal infections, improving survival rates, and safeguarding long-term health in vulnerable newborn populations.

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